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Viral infections are believed to initiate the pathogenesis of this syndrome although the definite proof remains elusive

There are six main substance groups that cause damage to peripheral sensory and motor neurons, resulting in development of CIPN: the platinum-based antineoplastics (particularly oxaliplatin and cisplatin), the vinca alkaloids (particularly vincristine and vinblastine), the epothilones (ixabepilone), the taxanes (paclitaxel, docetaxel), the proteasome inhibitors (bortezomid) and immunomodulatory drugs (thalidomide)