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reported that the novel aldehyde dehydrogenase 2 (ALDH2) activator, AD 9308, significantly enhanced both systolic and diastolic cardiac function in STZ-induced diabetic mice

Senapati J, Fiskus WC, Daver N, Wilson NR, Ravandi F, Garcia-Manero G, Kadia T, DiNardo CD, Jabbour E, Burger J, Short NJ, Alvarado Y, Jain N, Masarova L, Issa GC, Qiao W, Khoury JD, Pierce S, Miller D, Sasaki K, Konopleva M, Bhalla KN, Borthakur G , Pemmaraju N