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Metzeler KH et al (2013) A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid leukemia

The copper ion is released gradually as the peptide is metabolized, providing sustained signaling

, Phase 1 studies evaluated safety, tolerability, and pharmacokinetic characteristics Early data from Phase 2 investigations provided insights into biological activity and physiological responses

Therefore, we asked whether TrkB signalling deficiency in iSPNs could trigger DA dysfunction

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