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Conclusion In summary, the present review outlined the dual role of ferroptosis in LC, highlighting both its detrimental and therapeutic effects, and biological agents that target ferroptosis as potential therapies for LC, with certain compounds inducing ferroptosis and decreasing tumor cell resistance

Moreover, ebselen increased the expression of GPX2 and GPX4 in SGNs after peroxynitrite injury (Supplementary Figure 3), which is consistent with previous studies that ebselen can increase the expression of GPX2 or GPX4 in rat stomach ( With regard to how GPX1 influences the apoptotic outcome, the pieces of evidence indicate that GPX1 may influence several steps in apoptotic cascades via regulating oxidant accumulation

Copper-iron bimetallic sulfide nanoparticles (CFS NPs), synthesized through a valence-regulated metal ion strategy, enable the controlled release of Cu + and Fe 2+ , effectively catalyzing Fenton-like reactions

DFO, an FDA-approved iron chelator, effectively reduces hydroxyl radical generation and attenuates brain injury in experimental stroke models (150, 151)

Phagocytic leukocytes also produce and release cytokines, including interferons, which have antiviral activity (87)