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Dabrafenib treatment significantly upregulated the expression of Axl receptor tyrosine kinase (Axl) in the spinal cord tissues of EAE mice, increased the expression of System Xc , GPX4, and Ferritin, and decreased the expression of CD71, ACSL4, and POR

In erythrocytes, NO may react with hemoglobin, yielding S-nitrosohemoglobin [173]

Focal sinusoidal dilatation and peliosis hepatis have been observed in the rodent liver after treatment with nitrosamines, pyrrolizidine alkaloids or glucocorticoids (Greaves 2007;Ruebner, Watanabe, and Wand 1970