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Effect of Astragalus Polysaccharide on TGF-1/Smads Signal Pathway in Rats with Liver Fibrosis

Acknowledgements This work was financially supported by the NSFC (T2422030 (WL), 82172081 (J.Q.) and 32471462 (J.Q.)), CAMS Initiative for Innovative Medicine (2021-I2M-1-043 (W.L.)), the Science and Technology Program of Tianjin, China (22JCYBJC01000 (W.L.) and 22JCQNJC01640 (J.Q.)), and the Fundamental Research Funds for the Central Universities (2021-RC350-006 (W.L.))

Bacterial lipopolysaccharide increases serotonin metabolism in both medial prefrontal cortex and nucleus accumbens in male wild type rats, but not in serotonin transporter knockout rats

Although current antipsychotic therapies can alleviate certain manifestations of the disease, particularly those associated with dopaminergic hyperactivity, they often provide limited benefit for negative and cognitive symptoms and do not correct the underlying biological heterogeneity of schizophrenia

Conclusions GLP-1R KO mice exhibit impaired brain glucose metabolism to high doses of exogenous glucose, and they also have reduced functional connectivity