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In vitro , quercetin can promote oocyte maturation and early embryonic development in humans and aged mice by clearing mitochondrial reactive oxygen species (ROS), reducing apoptosis, and improving autophagy ( Caenorhabditis elegans with heat-stress tolerance by regulating insulin-like signaling and the p38-mitogen-activated protein kinase (MAPK) pathway (Sugawara and Sakamoto, 2020)

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It is seen in this figure that mDia1 activates MAPKs including ERK1/2, p38 and c-JNK leading to the activation of their respective substrate, transcription factors which eventually enters the nucleus and transcribes downstream genes responsible for cell proliferation and apoptosis

The expression of autophagy genes is increased in HepG2 ATP7B-KO and PHH WD cells To validate the copper-dependent gene regulation in HepG2 and HepG2 ATP7B-KO cells, both were cultured in RPMI medium, contrasting with the GSE107323 dataset, which used DMEM and RPMI medium, respectively

GBD 2021 Adult BMI Collaborators