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It also extends to classic Watson-Crick pairings where one or both of the nucleotides has been modified as described herein, e.g., by a those modification or a phosphate backpone modification

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doi: 10.1006/bbrc.2001.5659

We used human adipocytes as the model system and show that vitamin B 12 restriction induced cholesterol biosynthesis in adipocytes by limiting cellular AdoMet levels and modulating the methylation of genes which regulate cholesterol biosynthesis