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Description

apart from Mischley et al

AS: Writingoriginal draft

(2018) 12:CD012378

When GPX4 is removed from mice models, adults lost body weight and died within 2 weeks due to mitochondrial damage, decreased electron transport chain activity (Yoo et al., 2012)

In the quest for novel metabolic targets, approaches such as CRISPRCas9-mediated synthetic lethality screens targeting metabolic genes offer a pathway for identifying specific metabolic targets of interest, particularly in vivo