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As previously mentioned, examples of longevity resulting from disruption of the GH/IGF-1 and/or insulin signaling pathway are mainly derived from early life manipulations 6,17,18 , whereas brief exposure to GH (and IGF-1) treatment early in development is sufficient to partially abrogate the exceptional longevity of Ames Dwarf mice 20

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Dalmasso M, Strain R, Neve H, Franz CM, Cousin FJ, Ross RP, Hill C

10.1016/j.immuni.2020.06.004 161 LuB.ChenX

These results suggest that GPx1 protects against atherogenesis in blood vessels and virus-induced myocarditis by reducing ROS levels