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The ecological imbalance of intestinal flora, alterations of intestinal cell permeability, liver injury, endoplasmic reticulum stress, abnormal activation of cellular signaling pathway, as well as dietary and genetic factors of patients, have all been implicated in the occurrence of NAFLD (Williams et al.,

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It is to measure risk more accurately, think in cumulative exposure rather than 10-year probability, use apoB where standard markers are most likely to understate burden, intervene earlier when trajectory, family history, metabolic phenotype, or imaging warrant it, and keep treatment intensity proportional to both the evidence and the person in the consulting room

This could be due to ga enetic disorder, inadequate intake, diarrhoea, liver or kidney disease, and use of certain medications