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Free DOX was mainly localized inside nucleus due to its passive diffusion and high affinity toward DNA

Ohkawa K, Tsukada Y, Dohzono H, Koike K, Terashima Y

These are recognised class effects associated with GLP-1based therapies

If response is adequate, treatment is continued for one week as most side effects of NSAIDs appear in the first week

The development of biomarkers and imaging tools capable of confirming synaptic target engagement in vivo will be critical for successful clinical translation (Jackson et al., 2019)