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Kornfield, 1895)

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However, since blunted IGF-IR activity in the PeF area induces changes in the ECG, as seen in the Firoc mouse, and until now only orexin neurons are known to produce these changes 38 , we may conclude that most of our results may be explained by a direct activation of orexinergic neurons by IGF-I, facilitating in this way wakefulness

206 A meta-regression analysis indicated that glutamine and glutamate levels are decreased in the PFC, which is correlated with the therapies to MDD