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The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

The trial demonstrated a statistically significant improvement in OS and PFS for patients randomized to pemetrexed in combination with pembrolizumab and platinum chemotherapy compared with placebo, pemetrexed, and platinum chemotherapy (see Table 10 and Figure 1)

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It lowers the glass transition temperature of the dried cake, essentially allowing molecular movement to resume at storage temperatures that would otherwise be safe