The treatment with Paeonol shows effective antifungal and antibiofilm activity against biofilms containing Candida albicans and/or Cryptococcus spp (Qian et al., 2022)
5.4 Toxicology, pharmacokinetics, and standardization of Rhodiola rosea Rhodiola rosea is generally regarded as safe and well tolerated when administered at clinically relevant doses
Bessar H, Venditti I, Benassi L, Vaschieri C, Azzoni P, et al
Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes
On deeper skin tones, the biggest risk is not the ingredients themselves but irritation from using them too aggressively, because inflammation can leave post-inflammatory hyperpigmentation that makes the skin darker than before