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Sections were viewed via a fluorescence microscope

More preferably, the GLP-1 receptor agonist is a peptide comprising or consisting of the sequence: Xaa 7 -Xaa 8 -Glu-Gly-Thr-Xaa 12 -Thr-Ser-Asp-Xaa 16 -Ser-Xaa 18 -Xaa 19 -Xaa 20 -Glu- Xaa 22 -Xaa 23 -Xaa 24 -Xaa 25 -Xaa 26 -Lys-Phe-lle-Xaa 30 -Xaa 31 -Leu-Val-Xaa 34 -Xaa 35 - Xaa 36 -Xaa 37 -Xaa 38 -Xaa 39 (SEQ ID NO:1), wherein: Xaa 7 is L-histidine, imidazopropionyl, a-hydroxy-histidine, D-histidine, deamino-histidine, 2- amino-histidine, B-hydroxy-histidine, homohistidine, Na-acetyl-histidine, Na-formyl- histidine, a-fluoromethyl-histidine, a-methyl-histidine, 3-pyridylalanine, 2-pyridylalanine, or 4-pyridylalanine

This can be worsened by the addition of more complex regimens of chemotherapy and radiotherapy, as for many patients, a multimodal therapy is warranted to improve oncologic outcomes

Author contributions YW: Supervision, Conceptualization, Writing original draft, Formal analysis, Data curation