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IGF-1 treatment promoted oligodendrocyte development and myelination in a spatiotemporal manner To determine whether systemic treatment with IGF-1 during the early perinatal period influences myelination, the total number of oligodendrocytes (Olig2 + cells) was counted, and the immunoreactive area of Olig2 and MBP were quantified in ROIs of WM tracts, including IGWM, IC, PvWM projections, and hippocampal subregions of preterm pigs at P5 and P9

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