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In the hippocampus, taurine acts as an inhibitory neurotransmitter, supplementing GABA, whose levels are known to decrease in individuals with severe MDD

10.1109/BIBM.2013.6732641 48 HuangW

Activation of Ret triggers two key signaling pathways: the PI3K/Akt pathway directly inhibits the mitochondrial translocation of the pro-apoptotic protein Bax, and the MAPK/ERK pathway enhances mitochondrial biogenesis by upregulating peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), and the Src kinase pathway is involved in regulating the survival and axonal regeneration of dopaminergic neurons [70]

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