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Administer orally on the back of animal's tongue

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Add 12mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial

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1950s: Clinical trials, including those by the British Medical Research Council, established intramuscular injections (15-30 mcg initially, later 1,000 mcg) as the standard for pernicious anemia, achieving remission in 85-90% of patients within 6-12 months