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It participates in the transport of fatty acids to the mitochondrion and in the balance of acyls, so it is studied in energy metabolism and recovery

The observation in RCC aligns with our findings showing that HIF2 KO NSCLC cells are dependent on -KG synthesis, which is facilitated by PHGDH and phosphoserine aminotransferase 1 (PSAT1) reactions, and consequently indicates that these cells are specifically sensitive to PHGDH inhibitors rather than to downstream targeting of SHMT by sertraline

"Sentiment toward these guys is as negative as it's ever been," Emily Field, head of European pharmaceuticals research at Barclays, told CNBC over the phone Wednesday

Dietary methionine restriction ameliorates the impairment of learning and memory function induced by obesity in mice

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