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Not only that, SeNPs can also enhance anti-tumor immune responses by exerting immunomodulatory effects, for example, SeNPs pretreated T cells can significantly up-regulate the expression of cytotoxicity-related molecules such as NKG2D, CD16 and IFN- compared with T cells treated alone, while down-regulating the PD-1 expression of T cells and significantly enhancing the antitumor activity of V9V2 T cells (V9V2 T cells are a subset of peripheral T cells that have been shown to have good antitumor activity), with stronger tumor killing and tumor growth inhibition effects (157)