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Data from a randomized, double-blind, placebo-controlled pilot study investigating the efficacy of a Na v 1.7 antagonist, XEN402, indicate that it is effective in patients with inherited erythromelalgia, but so far, this compound has not been assessed in CIPN [4]

Of related interest is a report that dietary glycine prevents development of cardiac hypertrophy in rats subjected to pressure overload.71 This effect may be mediated by glycine receptors expressed on cardiomyocytes.27,71 IMPACTS ON CANCER, CONNECTIVE TISSUE, AND THE CENTRAL NERVOUS SYSTEM Glycine might prove to have some utility in cancer management

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Clin Rheumatol 18 : 114121 McBeth J et al

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