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2.2.4 FSP1 and other emerging regulatory factors Alongside the critical role played by the GPX4 system, the ferroptosis suppressor protein 1 (FSP1)-coenzyme Q10 (CoQ10) pathway independently regulates ferroptosis ( Additionally, recent findings have identified GTP cyclohydrolase-1 (GCH1), dihydroorotate dehydrogenase (DHODH), and several other factors as ferroptosis regulators, further expanding the ferroptosis network and offering new directions for elucidating ferroptosis in OA ( 2.3 Overview of ferroptosis-associated changes in OA tissues Recent studies have established a strong association between ferroptosis and the pathological features of OA, including cartilage degeneration, subchondral bone remodeling, and synovial inflammation

These fall into the following general categories: pyrimidines, polyenes, allylamines, azoles, echinocandins, and heterocyclic benzofurans

10.1007/s12223-022-00981-6 42 LouH.LinJ.GuoL.WangX.TianS.LiuC.et al (2019)

Ye et al., 2004

Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2