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Glutamate consumption by aminotransferases to generate NEAAs has also been indicated to be required for tumor growth in diverse cancer types 29,40,41,42

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Another study showed that elevated insulin levels promote the proliferation of thecal cells and increase the secretion of androgens, including luteinizing hormone (LH), while also upregulating the expression of cytochrome P450 and insulin growth factor-1 (IGF-1) receptors (107)