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The sample was limited to males to avoid the influence of menstrual cyclical changes of hormones on reaction times 48 and due to known differences in biochemical responses of the brains of males and females to caffeine, based on animal models of ADHD 49

Hagemann, The tumor microenvironment at a glance

Topical administration (HAIC, PIPAC, and HIPEC) may be a feasible and promising strategy to increase antitumor activity while reducing neurotoxicity due to its low systemic exposure and high local concentration (Yamashita, 2004

Owens, R