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Sharifi-Rad J

I published my first paper on the topic in 1994

Halestrap et al., 2002) which results in the opening of the mitochondrial permeability transition pore (MPTP) and allows the equilibration of small solutes and the release of pro-apoptotic proteins from the intermembrane space

Polymorphisms in GSTM1, GSTT1, and GSTP1 are generally not associated with the development of renal cell carcinoma in certain populations while the active genotypes of GSTM1 and GSTT1 are linked to an increased renal cell carcinoma risk in individuals exposed to pesticides