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Meng T, et al

280 Furthermore, activation of the inflammation-related NLRP3 inflammasome signaling pathway in different types of neural cells was closely associated with high cholesterol load, which triggered neuroprotective properties in activated microglia but promoted oxidative stress in neurons, further enhancing the expression of NLRP3 inflammasomes, inducing neuronal pyroptosis, and impairing the phagocytic capacity of microglia

According to the literature, H 2 O 2 can activate the TRPM2 ion channels in macrophages, promoting calcium influx and mediating immune responses 42,43,44