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SOCS proteins bind JAKs or their receptors and act by (i) abolishing the kinase ability of JAK, (ii) abolishing the ability of JAK to bind to the receptor, (iii) blocking STATs from being recruited to the receptor, and (iv) mediating the ubiquitination of JAKs and STATs for degradation (124)

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GSK3 phosphorylates a series of substrates, including -catenin and Myc, resulting in degradation and/or inactivation, and thereby inhibiting cancer cell proliferation and metastasis 62

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10.1016/j.ejps.2021.106002 5 AzmoonfarR.MoslehiM.Shahbazi-GahroueiD.ShiriE.AziziM