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Consequently, a crucial task will be to select the more active agents and integrate them effectively in well-designed clinical trials incorporating predictive biomarkers such as gene mutations, amplifications, and immunohistochemical c-MET overexpression

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In addition, substitutions were limited to elements with similar electronic orbital characteristics, defined here as having the same dominant valence-orbital types with effectively identical electronic configurations near the band edges without introducing additional strongly correlated d or f states

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