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Since an intramolecular disulfide bond forms between the N- and C-terminal CRDs (Cys310-Cys629 and Cys303-Cys598), the higher amounts of reactive oxygen species cause Yap1 to undergo transitory redox-induced conformational changes that hide the NES

OptForce: An optimization procedure for identifying all genetic manipulations leading to targeted overproductions

Mazokopakis EE, Papadomanolaki MG, Fousteris AA, Kotsiris DA, Lampadakis IM, Ganotakis ES

Other authors have found that angiotensin II significantly stimulates peroxide formation in monocytes

The likely candidates were Wnt signaling ligand, which is reported to play important roles both in the differentiation of stem cells and in the development of fibrotic diseases [45, 46]