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Fibroblasts are the most frequent cells in the tumor stroma

This approach maximizes your chance of success while minimizing side effect risk

In various solid tumors, including gastric, breast, thyroid and hepatocellular carcinomas, the HGF/c-Met pathway was detected as a critical in cancer development [14]

Its overexpression is associated with a decrease in acquisition of MET, cyclin D1, and CDK4 (oncogene and cell cycle-related proteins), which eventually lead to are duction in cell growth and enhanced cell apoptosis in vitro and in vivo (Jiang et al., 2019)

In recent years, there has been a growing interest in developing targeted therapies to enhance wound healing and promote skin regeneration