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Cell Stress Chaperones 20:555574

ROS levels and localization can alter the redox status of effector proteins and transcription factors (TFs), which could affect T-cell responses ( 2 O 2 for a long time in vitro , the DNA-binding ability of NFAT and NF-B is selectively inhibited, resulting in the downregulation of IL-2 transcription (59)

However, Xc-system inhibition results in glutathione and Cys deficiencies, triggering ferroptosis ( GPX4, also known as phospholipid hydroperoxide glutathione peroxidase, consists of approximately 170 amino acids and has a molecular weight of about 19 kDa