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2 Chemical method Many chemical approaches have been suggested to produce NPs [228]

On a different angle, when subjected to DEN-induced hepatocarcinogenesis, overexpression of PGC-1 renders mice more prone to hepatocarcinoma development possibly by enhancing the expression of genes involved in fatty acids and triglycerides synthesis as well as by limiting ROS accumulation via increased antioxidant response 12

These effects are not "side effects" in the traditional sense but are direct pharmacological consequences of the drug's action

In addition, cisplatin is known to deplete mitochondrial antioxidant enzyme activities, a finding that has been verified by cisplatin-induced increases in lipid peroxidation and GSSG/GSH ratio 25,26,27,28

Alzheimers Dement (N Y) 8 (2022): e12268