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Hydrogel-based controlled drug delivery for cancer treatment: a review

Incorporating pharmacogenomic analyses and biomarker assessments within these trials will be critical for elucidating the determinants of interindividual variability and for informing the development of tailored treatment protocols

This goal may be achieved through the specific design and development of new agents that are not subject to tolerance development, or through the use of adjunct treatments that can minimize or reverse tolerance