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Among the 18 hybrid organoid conditions generated, only organoids with healthy HPCs were able to form proper biliary structures (although JAG1 mutation in EPC and MPC resulted in dysmorphic organoids), attesting that mutation in parenchymal cells drives the disease phenotype

Responsible prescribing means proper patient selection, evidence-informed dosing, baseline and follow-up lab monitoring where appropriate, documented informed consent, and clinical follow-up to assess response

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For example, in a three-month follow-up study where microbial diversity was assessed in post-acute COVID-19 patients, there was a decrease in the Chao index that estimate species richness, Simpson index (a measure of diversity) and -diversity, which collectively indicates unevenness and microbial depletion [14]

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