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Development of a tool for correlational analyses Since a secondary aim of this study was to examine potential relationships between the cecal microbiome and adipose tissue metabolome, a Python (v3.8) tool, which used modules from SciPy 39 , was created to expedite the correlational analyses between the cecal microbiome and the previously-published epididymal white adipose tissue (EWAT) metabolome 13

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Avoid intense facial treatments, exfoliation, or active skincare acids (AHAs/BHAs, retinol)

To help reduce the risk of lactic acidosis while taking Metformin, make sure to take the medication with meals to minimize stomach discomfort