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Because of the many functions that the gut microbiota fulfills, compelling evidence suggest that gut microbiota dysregulation could be directly associated with low-grade inflammation and a wide range of pathological conditions including obesity and metabolic disorders like type 2 diabetes [64, 65], inflammatory bowel disease (IBD) [66], gastrointestinal cancer [67] and psychiatric disorders, including BD [68]

449 Elucidating the binding activity of Nrf1 to the Hrd1 promoter in AD patientderived neurons could be highly interesting

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Thus, Fe-S cluster binding in SLC25A39 highlights the metabolite-sensing potential of these cofactors

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