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Methods: By using RNASeq data of CRC patients from The Cancer Genome Atlas (TCGA) database, we divided the patients into normal group(58 patients)and tumor group(446 patients), and analyzed the expression and prognostic value analysis of IGF-1,IGF1R and RAGE

J Physiol Pharmacol, 60(Suppl 7), 115-122

Extending these trials to clinical endpoints such as anemia, neuropathy, or cognitive change would provide more definitive information, but such studies would be considered unethical