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Renal disease SQOR dysfunction has emerged as an important pathogenic factor in many kidney diseases, with wide-ranging and complex effects

GSTP1 methylation: A tissue biomarker that performs well in several types of malignancies The promoter region of the GSTP1 gene is usually affected by methylation, and changes in methylation status suppress normal gene expression, which may lead to weakening or loss of its detoxification and antioxidant functions

We also found that the anti-RGMa antibody improved the reduction in doublecortin (DCX)-positive cells in the hippocampal dentate gyrus and mitigated memory deficits in both db/db mice and streptozotocin (STZ)-mediated insulin-deficient type 1 diabetic mice

da Silva GH, Alves AV, Duques P, Seva-Pereira T, Soares EC, Escanhoela CA