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Succination of proteins by Fumarate

Mechanistically, JTC801 disrupts lysosomal pH, leading to cholesterol accumulation and activation of SREBF2, a master transcriptional regulator of sterol biosynthesis

FIGURE 6 Although the etiology of the metabolites alterations in thyroid nodularity is quite challenging, there are no sufficient and comprehensive metabolomics studies with respect to the fluctuation of metabolites into the blood stream