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Different mechanisms were reported for Nrf2 activation by Curcuma longa extract including the improvement of Nrf2 translocation, keap-1 inhibition and affecting upstream signaling modulators of Nrf2 ( Allum sativa extract is rich with direct antioxidants, studies demonstrated its potent ability to induce the endogenous antioxidant machinery of Nrf2 by enhancing its phosphorylation (by PKC and p38 MAPK) and decreasing its ubiquitination ( Allium sativa extracts contain allicin, diallyl disulfied and diallyl trisulfide that are able to modify directly the Cys288 of keap-1 (Kim et al., 2014)

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