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Description

Organelles membrane structure limits the diffusion and transmission of ROS, leading to significant variation of the ROS concentration among these cellular compartments [44,45,46,47]

References 1 AhmadA

TM, JRP, AE, MTB, JJP are employees of Cour Pharmaceuticals, RE-is employee of invivotek, DIG - is employee of AstraZeneca

Analysis of advanced AD brain tissue has shown extensive abnormalities in the IGF signaling pathway compared to elderly controls, with significant downregulation of IGF-1 and its receptor gene expression [5, 6, 131]