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For instance, NCOA4-mediated ferritinophagy may impact the activity of glutathione peroxidase 4 (GPX4), as increased iron levels can deplete intracellular antioxidants like glutathione, indirectly inhibiting GPX4 function and thereby facilitating ferroptosis (Mancias et al., 2014)

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Transferrin saturation/hepcidin ratio discriminates TMPRSS6-related iron refractory iron deficiency anemia from patients with multi-causal iron deficiency anemia

1 Introduction The world population has increased by 14% in the past 12 years, reaching the 8.0-billion milestone in 2022, and is expected to continue, peaking at 9.7 billion in 2050 and 10.9 billion in 2100 ( Plant cell culture (PCC) technology for commercial use has been deployed since the 1980s to produce pharmaceuticals, cosmetics, and, most recently, food ingredients ( Currently, two plant cell lines, scurvy grass (SG, Cochlearia danica , Brassicaceae) and rowan (RW, Sorbus aucuparia , Rosaceae), are being developed as potential novel food ingredients for commercialization at an industrial scale

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