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doi: 10.4049/jimmunol.0902584 117 MuXShiWXuYXuCZhaoTGengBet al

In renal biopsy tissue studies of CKD patients and mice models including UUO and renal ischemia-reperfusion injury, downregulation of GPx4 and upregulation of 4-hydroxynonenal were observed

These researches suggesting the potential involvement of ferroptosis in androgen-regulated seasonal testicular regression

In this way, high metabolic activity and its consequent increased NADPH production could affect ER function through GR activity, even though GR itself is not in the ER