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Photodiagn Photodyn Ther 38:102746

These changes in GSH metabolism could be triggered by oxidative stress and hydrogen peroxide accumulation, effects that are observed in nodules of sym40-1 mutants and are associated with the perception of nodule bacteria as pathogens rather than microsymbionts (Tsyganova et al., 2009

Additionally, genetic factors, including mutations in APP, presenilin 1 (PSEN1), and presenilin 2 (PSEN2), as well as the 4 allele of apolipoprotein E (APOE4), increase the risk of AD by influencing amyloid and tau pathology (Karran and De Strooper 2016 )