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In addition, there are some author limitations of this study, such as the death rate in the MES group, which was 50%, which is higher and could not be acceptable as no reasons were provided

A reduction in the mRNA level of inflammatory mediators (iNOS, IL-6, IFN-, and TNF-) and increased expression of HSP 70 and 90 and antioxidant proteins such as HO-1, NQO-1, glutathione reductase, glutathione peroxidase 2, and GST-pi were observed (Park et al., 2020)

However, prolonged alcohol use can lead to the compensatory upregulation of NMDA receptors, resulting in an excitatory state that may worsen mood dysregulation

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doi: 10.1016/j.imbio.2022.152286 37 AldekwerSGoncalves-MendesNBingulaRMartinrocheGLanchaisKRougeSet al