glutathione peroxidase 5 function GPX4-independent ferroptosis—a new strategy in disease's therapy Glutathione and the Cofactors

Mitochondrial dysfunction is a common event in the mechanism leading to cell death [37], and, recently, it has been found to be an essential step for the killing of non-small-cell lung (NSCLC) carcinomas which are resistant to conventional treatments [38]

Platelets and Alzheimer's disease: potential of APP as a biomarker

doi:10.1016/j.ymgmr.2016.10.003 115

130 Another small study also reported improvements in glucose metabolism in response to 1,000 mcg chromium picolinate supplementation in obese women with PCOS

Three physiological GPX4 isoforms, including cytosolic (cGPX4), mitochondrial (mGPX4), and nuclear (nGPX4), have been identified