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However, by using triple time-of-flight (TOF), all fragment ions can be collected and a large number of high-resolution fragment ions can be combined, greatly improving analysis sensitivity

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For instance, glioblastoma multiforme (GBM) cells shifted from glycolysis to fructolysis under glucose deprivation, activating transcription factor ATF4 and inducing the expression of fructose metabolic proteins GLUT5 and ALDOB (88)

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Cancer proteogenomics: current impact and future prospects

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doi:10.1038/s41598-017-09767-0 78

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