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Chen J.F., (2019)

The bacteria in the mouth can enter the bloodstream and cause inflammation in other parts of the body

Due to its high susceptibility to undergo hyperoxidation even at low levels of oxidative stress its chaperone function is frequently involved in the oxidative folding of various ER resident proteins, likely in cooperation with protein disulfide isomerase (PDI) [68]

In the CNS, decreased or depleted levels of BDNF are closely associated with ptau, A accumulation, neuroinflammation, and neuronal apoptosis [67]

Its primary function is the regulation of sleep processes, specifically promoting the slow-wave sleep phase known as the delta phase