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10.1016/S0166-6851(00)00243-7

Combination of metformin, sodium oxamate and doxorubicin induces apoptosis and autophagy in colorectal cancer cells via downregulation HIF-1

10.1007/s00280-013-2196-8 11 ChenP.WienckeJ.AldapeK.Kesler-DiazA.MiikeR.KelseyK.et al

Exogenous supplementation of methionine alleviated the stress by reducing the need to divert the intracellular cysteine pool towards methionine production, thereby enhancing the mycothiol generation critical for mitigating the ROS levels at acidic pH